Muscle denervating agents such as Botox® should be administered only as often as it is necessary to do so. I find that this ranges from every three to every six months, depending upon what is being treated and the general condition of one’s skin. Having Botox® or a similar muscle denervating agent administered more frequently than that is not harmful, but I have not found that patients in my practice require that it be administered any more frequently than every three months. More frequently, it can be administered less frequently, especially after one has had it regularly for several years. On the other hand, it is my opinion that having Botox® injections administered less than twice yearly most often results in underperformance of the product.